Query   'Conserved C-Terminal (CCT) domain'  matched   20 Records

Record No : 1

Instance ID10931
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVT
Bait Uniprot AccessionQ80UE6
Bait Uniprot IdentifierWNK4_MOUSE
Bait Gene NameWnk4
Bait OrganismMus musculus (Mouse)
Sequence Position996-1000
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20931
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15930150
CommentsVolume sensitivity of cation-chloride cotransporters is modulated by functional interaction between the conserved C-terminal (CCT) domain of mouse Ste20-related kinase Stk39/Spak and the RFxV docking motif of mouse Serine/threonine-protein kinase Wnk4

Record No : 2

Instance ID10932
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVH
Bait Uniprot AccessionP55014
Bait Uniprot IdentifierS12A1_MOUSE
Bait Gene NameSlc12a1
Bait OrganismMus musculus (Mouse)
Sequence Position16-20
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Alanine scanning
Interaction ID20932
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12386165
CommentsMouse Kidney-specific Na-K-Cl symporter Slc12a1/Nkcc2 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif

Record No : 3

Instance ID10933
Regular ExpressionRF[^P][IV]x
Motif InstanceRFTVS
Bait Uniprot AccessionQ80YE4
Bait Uniprot IdentifierLMTK1_MOUSE
Bait Gene NameAatk
Bait OrganismMus musculus (Mouse)
Sequence Position1336-1340
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Y2H; Mutation analysis
Interaction ID20933
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17267545
CommentsThe regulatory domain of mouse stress-related kinase Stk39/Spak interacts with the regulatory domain of mouse Apoptosis-associated tyrosine kinase (Aatk/AATYK) through the RFxV docking motif (1336-1340) in the extreme COOH-terminus of AATYK

Record No : 4

Instance ID10934
Regular ExpressionRF[^P][IV]x
Motif InstanceRFSIT
Bait Uniprot AccessionQ80YE4
Bait Uniprot IdentifierLMTK1_MOUSE
Bait Gene NameAatk
Bait OrganismMus musculus (Mouse)
Sequence Position1346-1350
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Y2H; Mutation analysis
Interaction ID20934
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17267545
CommentsThe regulatory domain of mouse stress-related kinase Stk39/Spak interacts with the regulatory domain of mouse Apoptosis-associated tyrosine kinase (Aatk/AATYK) through the RFxV docking motif (1346-1350) in the extreme COOH-terminus of AATYK

Record No : 5

Instance ID10935
Regular ExpressionRF[^P][IV]x
Motif InstanceRFIVS
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1257-1261
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20935
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1257-1261)

Record No : 6

Instance ID10936
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVT
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1945-1949
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20936
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1945-1949)

Record No : 7

Instance ID10937
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVS
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1859-1863
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20937
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1859-1863)

Record No : 8

Instance ID10938
Regular ExpressionRF[^P][IV]x
Motif InstanceRFSVS
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1957-1961
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20938
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1957-1961)

Record No : 9

Instance ID10939
Regular ExpressionRF[^P][IV]x
Motif InstanceRFIVS
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1257-1261
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20939
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1257-1261)

Record No : 10

Instance ID10940
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVT
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1945-1949
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20940
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1945-1949)

Record No : 11

Instance ID10941
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVS
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1859-1863
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20941
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1859-1863)

Record No : 12

Instance ID10942
Regular ExpressionRF[^P][IV]x
Motif InstanceRFSVS
Bait Uniprot AccessionQ9H4A3
Bait Uniprot IdentifierWNK1_HUMAN
Bait Gene NameWNK1
Bait OrganismHomo sapiens (Human)
Sequence Position1957-1961
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20942
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16263722
CommentsThe human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1957-1961)

Record No : 13

Instance ID10943
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVT
Bait Uniprot AccessionQ96J92
Bait Uniprot IdentifierWNK4_HUMAN
Bait Gene NameWNK4
Bait OrganismHomo sapiens (Human)
Sequence Position1016-1020
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPR; X-ray crystallography; Mutation analysis
Interaction ID20943
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Pseudohypoaldosteronism type 2 (PHA2)
Inhibitor(s)Unknown
Reference(s)17721439
CommentsHuman Serine/threonine-protein kinase WNK4 interacts with the conserved C-terminal (CCT) domain of human Oxidative stress-responsive 1 protein (OXSR1) through its RFxV docking motif

Record No : 14

Instance ID10944
Regular ExpressionRF[^P][IV]x
Motif InstanceRFRVN
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Bait OrganismMus musculus (Mouse)
Sequence Position133-137
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20944
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse Oxidative stress-responsive 1 protein (Oxsr1) through its RFxV docking motif (133-137)

Record No : 15

Instance ID10945
Regular ExpressionRF[^P][IV]x
Motif InstanceRFRVN
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Bait OrganismMus musculus (Mouse)
Sequence Position133-137
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20945
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif (133-137)

Record No : 16

Instance ID10946
Regular ExpressionRF[^P][IV]x
Motif InstanceRFMVT
Bait Uniprot AccessionQ924N4
Bait Uniprot IdentifierS12A6_MOUSE
Bait Gene NameSlc12a6
Bait OrganismMus musculus (Mouse)
Sequence Position14-18
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H; Mutation analysis
Interaction ID20946
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12386165
CommentsMouse Electroneutral K-Cl cotransporter 3 (Kcc3/Slc12a6) interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif

Record No : 17

Instance ID10947
Regular ExpressionRF[^P][IV]x
Motif InstanceRFTIS
Bait Uniprot AccessionP55017
Bait Uniprot IdentifierS12A3_HUMAN
Bait Gene NameSLC12A3
Bait OrganismHomo sapiens (Human)
Sequence Position19-23
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20947
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18270262
CommentsHuman Na-Cl cotransporter SLC12A3/NCC interacts with the conserved C-terminal (CCT) domain of human Oxidative stress-responsive 1 protein (OXSR1) through its RFXI motif

Record No : 18

Instance ID10948
Regular ExpressionRF[^P][IV]x
Motif InstanceRFTIS
Bait Uniprot AccessionP55017
Bait Uniprot IdentifierS12A3_HUMAN
Bait Gene NameSLC12A3
Bait OrganismHomo sapiens (Human)
Sequence Position19-23
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20948
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18270262
CommentsHuman Na-Cl cotransporter SLC12A3/NCC interacts with the conserved C-terminal (CCT) domain of human STE20-related kinase STK39/SPAK through its RFXI motif

Record No : 19

Instance ID10949
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVD
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Bait OrganismMus musculus (Mouse)
Sequence Position77-81
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20949
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse Oxidative stress-responsive 1 protein (Oxsr1) through its RFxV docking motif (77-81)

Record No : 20

Instance ID10950
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVD
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Bait OrganismMus musculus (Mouse)
Sequence Position77-81
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20950
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif (77-81)


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)